The substance index

Four families.
Researched, not romanticized.

Each guide pairs effects, onset, and duration with honest difficulty ratings and harm-reduction context. Nothing here is a recommendation to use — it is information for people who will explore regardless, so they can do it more safely.

Choose a family

46 documented varieties across four families.

  1. 01 Psilocybin The most documented path, from gentle introductions to profound, ego-dissolving doses. 37 varieties Beginner → Experienced
  2. 02 Ketamine Dissociative and clinically studied — where context, dose, and setting matter more than almost anything else. 4 forms Caution advised
  3. 03 Mescaline Peyote, San Pedro and Peruvian torch — long, deliberate, deeply ceremonial experiences measured in hours. 3 cacti Long duration
  4. 04 Ayahuasca A potent traditional brew with real medication-interaction risks — where preparation is the whole safety margin. 2 brews Interaction risk

Start here

Knowledge is the first harm-reduction tool.

Before any variety, read how we think about set, setting, testing, and the exits.

Harm reduction → Crisis resources