Nasal Spray (Spravato)
Esketamine
FDA-approved esketamine nasal spray. Administered in certified healthcare settings for treatment-resistant depression.
- Relaxation
- Emotional Release
- Dissociation
- Light
- Relaxed
- Calm
- Loving
- Introspective
Dissociative · 4 forms
Ketamine
Ketamine is a dissociative anesthetic with a genuine clinical evidence base — and a real potential for harm when used outside of a supervised context. Dose precision, setting, and physical safety (never alone, never near water, never combined with depressants) matter more here than with almost any other substance in this index.
The forms below differ enormously in how they are taken and how fast they act. We describe them so that the risks are legible, not to endorse non-clinical use. Bladder damage and dependence are real consequences of frequent use.
Safety note Ketamine carries risks of dependence, bladder damage, and dangerous interactions with alcohol and other depressants. Clinical ketamine should only be used under medical supervision.
The catalog
4 documented varieties, described honestly.
Sublingual Troche
Ketamine HCl
Dissolves under the tongue over 15-20 minutes. Common for at-home therapeutic use under medical supervision.
- Relaxation
- Introspection
- Emotional Release
- Warm
- Relaxed
- Calm
- Introspective
- Loving
IV Infusion
Ketamine HCl
Administered intravenously in a clinical setting, typically over 40 minutes. Provides precise dosing control.
- Dissociation
- Introspection
- Relaxation
- Heavy
- Warm
- Relaxed
- Calm
- Introspective
- Profound
Intramuscular
Ketamine HCl
Injected into muscle tissue in clinical settings. Faster onset than sublingual, used in therapeutic contexts.
- Dissociation
- Visual Distortions
- Introspection
- Heavy
- Warm
- Tingly
- Profound
- Introspective
- Calm
Before you go further
Read the safety philosophy first.
None of this is a recommendation to use. If you are exploring anyway, set and setting, testing, and a plan for the exits matter more than any variety on this page.